![]() During the same year, tetanus was produced in animals by injecting them with samples of soil. The muscle stiffness usually begins in the jaw (lockjaw) and neck and then becomes generalized.Īlthough records from antiquity (5th century BCE) contain clinical descriptions of tetanus, it was in 1884 when tetanus was first produced in animals by injecting them with pus from a fatal human tetanus case. It is characterized by generalized rigidity and convulsive spasms of skeletal muscles. ![]() Tetanus is an acute, often fatal, disease caused by an exotoxin produced by the bacterium Clostridium tetani. Tetanus toxoid developed in 1924 and widely used during World War II.Characterized by generalized rigidity and convulsive spasms.Caused by exotoxin produced by bacterium Clostridium tetani.
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